Customized anti-COVID treatments available thanks to a Centro Diagnostico Italiano (CDI) and Bracco Imaging project

Milan, Italy , 01/18/2021

The CDI project is called the “AI-for-COVID Imaging Archive”, which is already openly available online for the entire international scientific community. At the heart of the project is an innovative digital platform that gives doctors and healthcare professionals access to a database of radiographic images of COVID patients. By applying artificial intelligence for diagnostic purposes, the project enables doctors to obtain a clearer understanding of the progress of COVID-19 in patients, which makes for better triage in hospitals and facilitates the delivery of personalized and timely treatments.

The platform has been developed as part of an all-Italian project called AI-for-COVID promoted by Centro Diagnostico Italiano (CDI Italian Diagnostic Centre – Bracco Group healthcare services). CDI, which has been working in the fields of Radiomics and Genomics for some time, is running the project in collaboration with Bracco Imaging and several major public and private clinics and research institutes. Specifically, CDI has availed itself of the assistance of the following prominent and highly reputed treatment and research hospitals (IRCCS), public-sector local hospitals (ASST) and research institutes: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Milan), Fondazione IRCCS Policlinico San Matteo (Pavia), Azienda ospedaliero-universitaria Careggi (Florence), ASST Santi Paolo e Carlo (Milan), ASST Fatebenefratelli-Sacco (Milan), and ASST Ospedale San Gerardo (Monza), and Ospedale Casa Sollievo della Sofferenza (S.G.Rotondo).

Predictive diagnostic imaging through radiomics

As Sergio Papa, director of diagnostic imaging at CDI, explains: “Radiological imaging is playing a crucial role in diagnosing COVID-19 patients and determining treatment options. Effectively, what we have done is to recruit Radiomics (which, along with Genomics, represents the new frontier of personalized medicine) into the battle against this terrible pandemic by putting valuable medical data at the disposition of all doctors and hospitals. Diagnostic imaging generates a vast volume of data that, thanks to the power of artificial intelligence, can be correlated to the clinical development and course of the disease. Our AI-for-COVID project has given a fresh impulse to our research into the pathology caused by COVID, with particular regard to the damage it causes the lungs, and is helping us to implement targeted measures for patients whose pre-existing conditions render them more susceptible to the deleterious effects of the disease.

More than 800 X-rays already uploaded to the “AI-For-Covid Imaging Archive”

By referencing the AI-For-Covid Imaging Archive, doctors can make use of chest X-rays taken upon hospital admission to identify which patients are at greatest risk of pulmonary deterioration and therefore most liable to require mechanical ventilation. In other words, artificial intelligence provides a practical tool for predictive diagnostic imaging. The open-access platform, which is already available for the entire international scientific community at the URL aiforcovid.radiomica.it, currently contains over 800 chest X-ray images that are associated with critical clinical information acquired at the same time as the X-rays were taken.

The role of Istituto Italiano di Tecnologia (IIT) of Genoa and Università Campus Bio-medico of Rome in the development of the algorithms

Istituto Italiano di Tecnologia (IIT: the Italian Institute of Technology) of Genoa, the Campus Bio-Medico University of Rome (UCBM) and the CDI and Bracco Imaging team analysed the data and developed the AI algorithms for the project, while Amazon Web Services (AWS) provided important help in setting up the digital platform. As part of its Diagnostic Development Initiative, AWS has supported the AI-for-COVID project, recognizing it as one of the most innovative international initiatives of its type. The platform incorporates a range of AWS technologies, including the machine-learning and artificial intelligence capabilities of Amazon SageMaker, a fully managed service for creating, training and deploying machine learning models, as well as for data processing and analytics.

Diana Bracco, Chair and CEO of the Bracco Group, expresses her satisfaction

Diana Bracco, Chair and CEO of the Bracco Group, declared, “I am delighted to see Centro Diagnostico Italiano working on this project alongside Bracco Imaging and many other public and private clinics and research institutes. Thanks to the application of artificial intelligence to diagnostic imaging, a sector in which we are a world leader, we have been able to contribute to the fight against the pandemic. In the area of Big Data and Radiomics, CDI has always been at the forefront, leading the way in applying pioneering techniques for analysing radiological data and integrating them with genomic and histopathological data. Successful research nowadays entails integrating the knowledge of scientists from several different fields and adopting a multidisciplinary approach that is not circumscribed by cultural boundaries.

Scientific paper already available for consultation from Cornell University

The preliminary results of the CDI-Bracco Imaging research project are summarized in the article: “AIforCOVID: predicting the clinical outcomes in patients with COVID-19 applying AI to chest-X-rays. An Italian multicentre study”, which is available in preview as an open-access document at the Cornell University website.

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The Bracco Group, through its subsidiary Bracco Imaging operates throughout the world both directly or indirectly.

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The Bracco Group exists since 1927, when Elio Bracco founded the Italian E. Merck company branch.

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