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  1. Home
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  3. Interventional cardiology
  4. Contrast agents

  5. Iomeron 400

Iomeron®

 

Iomeron® is a tri-iodinated non-ionic monomeric contrast medium for radiology 7

 

An injectable solution at a higher iodine concentration allows a greater peak of enhancement in a shorter time from the injection when injected at the same volume and flow rate compared to a solution at a lower iodine concentration 8.

Iomeron® has interesting favorable properties, such as

 

  • the lowest viscosity at given concentration among iso-osmolar contrast media (IOCM) and low-osmolar contrast media (LOCM) 7;
     
  • the lowest osmolality among monomeric LOCM 7;
     
  • one formulation with the highest iodine concentration (400 mgI/mL) available on the market.

 

Iomeron® (Iomeprol) is Bracco's latest generation contrast agent. Launched in 1995 9, this tri-iodinated non-ionic contrast agent has quickly become the preferred choice for many practicing clinicians 9. Its unique and innovative profile can boast the highest concentration (400 mgI/mL), nonionic agent ever approved in the world 10.

 

Iomeprol is currently registered in more than 40 countries worldwide, including all major European & Middle Eastern countries, Japan and the Asian Pacific. This agent represents a step forward in its class. Iomeprol has become the number one choice for many clinicians for many reasons – including:

 

  • a unique product that combines the lowest viscosity among non-ionic agents and a very low osmolality compared to other available nonionic monomeric agents 10;
     
  • Iomeron® is readily available in a wide variety of iodine concentration and volumes for clinical use;
     
  • in first pass dynamic CT imaging, at equal flow rate and total iodine dose, iomeprol 400 mgI/mL, can provide better contrast enhancement and image quality than contrast solutions at lower iodine strength 11, 12, 13;
     
  • in a multicenter, randomized, double-blind, parallel-group comparison of Iomeron® and iodxanol in coronary CTA, observed mean heart rate changes after intravenous contrast injection were generally small during the examination and comparable for Iomeron-400 and iodixanol 320 14;
     
  • a prospective intra-individual study showed that a low-dose radiation exposure acquisition protocol, in conjunction with the use of Iomeron -400, provides substantially reduced radiation exposure while maintaining a constant CNR and good image quality compared to a standard protocol using a lower concentrated contrast medium in CTA examinations 15;
     
  • a large study compared the effects of Iomeprol-400 and Iodixanol-320 on kidney function in patients with pre-existing chronic kidney diseases (CKD) undergoing CT examinations. Based on the results, the authors of the study concluded: "The incidence of CIN was significantly higher after the IV administration of iodixanol-320 than iomeprol-400 in patients with moderate-to-severe CKD. The mean increase in SCr from baseline was also higher in patients receiving iodixanol. Characteristics of the individual contrast agents other than osmolality may be important in causing nephrotoxicity" 16.

 

Contrast Induced Nephropathy (CIN) 

1) High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography:iopromide 370 versus iomeprol 400.

 

Cademartiri F, de Monye C, Pugliese F, Mollet NR, Runza G, van der Lugt A, Midiri M, de Feyter PJ, Lagalla R, Krestin GP.Invest Radiol. 2006 Mar;41(3):349-53.

 

View

 

 

2) MDCT angiography of the pulmonary arteries: influence of iodine flow concentration on vessel attenuation and visualization.

 

Schoellnast H, Deutschmann HA, Fritz GA, Stessel U, Schaffler GJ, Tillich M. AJR Am J Roentgenol. 2005 Jun;184(6):1935-9.

 

View

 

 

3) Does iodine concentration affect the diagnostic efficacy of biphasic spiral CT in patients with hepatocellular carcinoma?

 

Marchianò A., Spreafico C., Lanocita R., Frigerio L., Di Tolla G., Patelli G., Garbagnati F., Heiman F., Taroni P., Damascelli B. Abdom Imaging. 2005 May-Jun;30(3):274-80.

 

View

 

 

4) Multidetector-Row Computed Tomography

 

Hammerstingl et al.

 

5) Effect of iodine concentration of contrast media on contrast enhancement in multislice CT of the pancreas.

 

Fenchel S, Fleiter TR, Aschoff AJ, van Gessel R, Brambs HJ, Merkle EM.Br J Radiol. 2004 Oct;77(922):821-30.

 

View

 

 

6) Enhancement and safety of iomeprol-400 and iodixanol-320 in patients undergoing abdominal multidetector CT.

 

Romano L, Grazioli L, Bonomo L, Xu JR, Chen KM, Dore R, Vanzulli A, Catalano C. Br J Radiol. 2009 Mar;82(975):204-11. Epub 2008 Dec 8.

 

View

 

 

7) The chemistry of iomeprol and physico-chemical properties of its aqueous solutions and pharmaceutical formulations.

 

Gallotti A, Uggeri F, Favilla A, Cabrini M, de Haën C.Eur J Radiol. 1994 May;18 Suppl 1:S1-12.

 

View

 

 

8) Computed Tomography Contrast Enhancement Principles and the Use of High-Concentration Contrast Media.

 

Herman S.J., Comput Assist Tomogr. 2004 Jul-Aug;28 Suppl 1:S7-11.

 

View

 

 

9) Bracco internal data.

 

10) Iomeron® SPC

 

11) 16MDCT angiography of aortoiliac and lower extremity arteries: comparison with digital subtraction angiography.

 

Albrecht T, Foert E, Holtkamp R, Kirchin MA, Ribbe C, Wacker FK, Kruschewski M, Meyer BC. AJR Am J Roentgenol. 2007 Sep;189(3):702-11.

 

View

 

 

12) High-concentration contrast media (HCCM) in CT angiography of the carotid system: impact on therapeutic decision making.

 

Schuknecht B. Neuroradiology. 2007 Jul;49 Suppl 1:S15-26.

 

View

 

 

13) Does iodine concentration affect the diagnostic efficacy of biphasic spiral CT in patients with hepatocellular carcinoma?

 

Marchianò A, Spreafico C, Lanocita R, Frigerio L, Di Tolla G, Patelli G, Garbagnati F, Heiman F, Taroni P, Damascelli B.Abdom Imaging. 2005 May-Jun;30(3):274-80.

 

View

 

 

14) Multicenter comparison of high concentration contrast agent iomeprol-400 with iso-osmolar iodixanol-320: contrast enhancement and heart rate variation in coronary dual-source computed tomographic angiography.

 

Becker CR, Vanzulli A, Fink C, de Faveri D, Fedeli S, Dore R, Biondetti P, Kuettner A, Krix M, Ascenti G. Invest Radiol. 2011 Jul;46(7):457-64.

 

View

 

 

15) Low-dose multidetector-row CT-angiography of abdominal aortic aneurysm after endovascular repair.

 

Iezzi R, Cotroneo AR, Giammarino A, Spigonardo F, Storto ML. Eur J Radiol. 2011 Jul;79(1):21-8. Epub 2009 Dec 16.

 

View

 

 

16) The ACTIVE Trial: comparison of the effects on renal function of iomeprol-400 and iodixanol-320 in patients with chronic kidney disease undergoing abdominal computed tomography.

 

Thomsen HS, Morcos SK, Erley CM, Grazioli L, Bonomo L, Ni Z, Romano L; Investigators in the Abdominal Computed Tomography: IOMERON 400 Versus VISIPAQUE 320 Enhancement (ACTIVE) Study.Invest Radiol. 2008 Mar;43(3):170-8.

 

View

Iomeron400 _ Summary of Products Characteristics 10/27/2023 pdf Download
MDCT E-lectures
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